There is or there are. Is there
any milk in the fridge?
How many students
in your class?
a very good beach near our hotel.
any cheap restaurants near here?
a university in Brighton?
I'm sorry, but
any shops open at this
time.
fifty states in the USA
any milk: how about lemon in
your tea?​

Is there any milk in the fridge?

How many students are there in your class?

There is a very good beach near our hotel.

Are there any cheap restaurants near here?

Is there a university in Brighton?

I'm sorry, but there aren't any shops open at this

time.

There are fifty states in the USA

There isn't any milk: how about lemon in

your tea?

do you know the wilsons? they*re a very friendly family.

определенный артикль the ставится перед именами собственными (фамилиями), обозначающими целиком всю семью. 

mr adams doesn'n work on monday, does he?

  mr adams works on tuesday, doesn't he?